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Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.
*Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen M.
Cancer Research 2010 Jan 15

High-throughput insertional mutagenesis screens in mice to identify oncogenic networks.
Kool J, Berns A.
Nature Reviews Cancer. 2009 Jun;9(6):389-99. Review.

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.
*Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A, Adams DJ.
Nature Protocols. 2009;4(5):789-98. Epub 2009 Apr 30.

Jump-starting cancer gene discovery.
Uren A, Berns A.
Nat Biotechnol. 2009 Mar;27(3):251-2. News & Views

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.
*Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M, Berns A.
Cell. 2008 May 16;133(4):727-41.

Co-occurrence analysis of insertional mutagenesis data reveals cooperating oncogenes.
de Ridder J, Kool J, Uren A, Bot J, Wessels L, Reinders M.
Bioinformatics. 2007 Jul 1;23(13):i133-41.

Detecting statistically significant common insertion sites in retroviral insertional mutagenesis screens.
de Ridder J, Uren A, Kool J, Reinders M, Wessels L.
PLoS Computational Biology. 2006 Dec 8;2(12):e166. Epub 2006 Oct 24.

Retroviral insertional mutagenesis: past, present and future.
*Uren AG, Kool J, Berns A, van Lohuizen M.
Oncogene. 2005 Nov 21;24(52):7656-72. Review.

Retroviral insertional mutagenesis: tagging cancer pathways.
Mikkers H, Berns A.
Adv Cancer Res. 2003;88:53-99. Review.

Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.
* Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE.
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11293-8. Epub 2002 Jul 31.

Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.
* Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, Russell R, DePinho RA, Lenz J, van Lohuizen M.
Nat Genet. 2002 Sep;32(1):160-5. Epub 2002 Aug 19.

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.
Mikkers H, Allen J, Knipscheer P, Romeijn L, Hart A, Vink E, Berns A.
Nat Genet. 2002 Sep;32(1):153-9. Epub 2002 Aug 19.

* shared first authorship